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Relenza
(Zanamivir) Information
Recommended
Anti-Viral Drugs - Oseltamivir
& Zanamivir - The Centers for Disease
Control and Prevention recommend the use of Tamiflu
(oseltamivir) or Relenza
(zanamivir) for the treatment and/or prevention
of infection with swine
influenza viruses.
Relenza Manufacturers Prescribing & Safety
Info - GlaxoSmithKline
Relenza
Table 1. Swine-origin influenza antiviral medication
dosing recommendations.
(Table extracted from IDSA
guidelines for seasonal influenza.)
| Agent, group |
Treatment |
Chemoprophylaxis |
| Relenza
(Zanamivir) |
| Adults |
Two 5mg inhalations (10 mg total) twice per
day |
Two 5mg inhalations (10 mg total) once per
day |
| Children |
Two 5mg inhalations (10 mg total) twice per
day (age, 7 years or older) |
Two 5mg inhalations (10 mg total) once per
day (age, 5 years or older) |
Uses of Relenza
(Zanamivir)
Relenza (Zanamivir) is used for the
treatment of uncomplicated acute illness due to
influenza infection.
It is important that you begin your
treatment with Relenza as soon as possible from
the first appearance of your flu symptoms. Take
2 doses on the first day of treatment whenever
possible if there are at least 2 hours between
doses.
Relenza
(Zanamivir) Diskhaler Pack Directions
Relenza is packaged in medicine disks
called ROTADISKS® and is inhaled by mouth using
a delivery device called a DISKHALER®. Each
ROTADISK contains 4 blisters. Each blister contains
5 mg of active drug and 20 mg of lactose powder
(which contains milk proteins). You should receive
a demonstration on how to use Relenza in the DISKHALER
from a healthcare provider. Before taking Relenza,
read the “Patient Instructions for Use.”
Make sure that you understand these instructions
and talk to your healthcare provider if you have
any questions. Children who use Relenza should
always be supervised by an adult who understands
how to use Relenza. Proper use of the DISKHALER
to inhale the drug is necessary for safe and effective
use of Relenza. The usual dose is 2 inhalations
of Relenza (1 blister per inhalation) twice daily
(in the morning and evening) for 5 days.
Relenza Side
Effects
Some patients have had breathing
problems while taking Relenza. This can be very
serious and need treatment right away. Most of
the patients who had this problem had asthma or
chronic obstructive pulmonary disease, but some
did not. If you have trouble breathing or have
wheezing after your dose of Relenza, stop taking
Relenza and get medical attention. In studies,
the most common side effects during treatment with
Relenza in adults and adolescents have been headaches;
diarrhea; nausea; vomiting; nasal irritation; bronchitis;
cough; sinusitis; ear, nose, and throat infections;
and dizziness. In children, the most common side
effects were ear, nose, and throat infections;
vomiting; and diarrhea. Other side effects that
have been reported, but were not as common, include
allergic reactions and rashes. This list of side
effects is not complete. Your healthcare provider
or pharmacist can discuss with you a more complete
list of possible side effects with Relenza. Talk
to your healthcare provider promptly about any
side effects you have. Please refer to the section
entitled “Important Safety Information About
Relenza”
for additional information.
Relenza Precautions
Some patients have had bronchospasm
(wheezing) or serious breathing problems when they
used Relenza. Many but not all of these patients
had previous asthma or chronic obstructive pulmonary
disease. Relenza has not been shown to shorten
the duration of influenza in people with these
diseases. Because of the risk of side effects and
because it has not been shown to help them, Relenza
is not generally recommended for people with chronic
respiratory disease such as asthma or chronic obstructive
pulmonary disease. If you develop worsening respiratory
symptoms such as wheezing or shortness of breath,
stop using Relenza and contact your healthcare
provider right away. If you have chronic respiratory
disease such as asthma and chronic obstructive
pulmonary disease and your healthcare provider
has prescribed Relenza, you should have a fast-acting,
inhaled bronchodilator available for your use.
If you are scheduled to use an inhaled bronchodilator
at the same time as Relenza, use the inhaled bronchodilator
before using Relenza. Read the rest of this leaflet
for more information about side effects and risks.
Other kinds of infections can appear like influenza
or occur along with influenza, and need different
kinds of treatment. Contact your healthcare provider
if you feel worse or develop new symptoms during
or after treatment, or if your influenza symptoms
do not start to get better.
Relenza
(Zanamivir) Drug Notes
Never share Relenza with anyone,
even if they have the same symptoms. If you feel
worse or develop new symptoms during treatment
with Relenza, or if your flu symptoms do not start
to get better, stop using the medicine and contact
your healthcare provider.
Missed Dose of Relenza
If you miss a dose, use it as soon
as you remember. If it is near the time for the
next dose, skip the missed dose and resume your
usual dosing schedule. Do not double the dose to
catch up.
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